Testosterone and Its Analogs as a Male Contraceptive

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Testosterone and Its Analogs as a Male Contraceptive

Male contraception by means of hormonal approach was initiated more than 60 years ago when men became azoospermic with administration of testosterone. The basic principle of male hormonal contraception is suppression of spermatogenesis. Exogenous testosterone/testosterone analogs alone or in combination with progestin have been tested for contraceptive efficacy by inhibiting gonadotropins relea...

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A multicentre study investigating subcutaneous etonogestrel implants with injectable testosterone decanoate as a potential long-acting male contraceptive.

BACKGROUND The combination of etonogestrel implants with injectable testosterone decanoate was investigated as a potential male contraceptive. METHODS One hundred and thirty subjects were randomly assigned to three treatment groups, all receiving two etonogestrel rods (204 mg etonogestrel) and 400 mg testosterone decanoate either every 4 weeks (group I, n = 42), or every 6 weeks (group II, n ...

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P-9: Investigate The Effects of Polyphenol Gossypol as A Male Antifertility Agents,How to Make Male Contraceptive?

Background: Gossypol is a polyphenol isolated from the cotton plant (Gossypium sp.). The substance, shows promise for use as a male contraceptive, is a derivative of cottonseed oil. Various species of animals have been tested and some are more sensitive than others, and in men it causes spermatogenesis arrest at relatively low doses. Materials and Methods: This routine data base study re-examin...

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LONG-ACTING CONTRACEPTIVE AGENTS: TESTOSTERONE ESTERS OF CYCLOALKYLCARBOXYLIC ACIDS

The synthesis of twenty five esters of testosterone (17β -hydroxyandrost- 4-en-3-one) is described. All esters are derivatives of cycloalkycarboxylic acids. Some of the esters possess α- , β -and/or & - substitution in the ester side-chain. The work was undertaken in order to evaluate long-acting male antifertility effect of such esters. Most of the compounds, especially compound No.1, wer...

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Exogenous Testosterone, Finasteride and Castration Effects on Testosterone, Insulin, Zinc and Chromium in Adult Male Rats

Background: Although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. The aim of the present study was to evaluate the effect of testosterone and finasteride administration and castration on serum levels of testosterone, insulin, zinc and chromium. Methods: Male adu...

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ژورنال

عنوان ژورنال: Advances in Sexual Medicine

سال: 2013

ISSN: 2164-5191,2164-5205

DOI: 10.4236/asm.2013.33a002